ABSTRACT
Background: A quality of life (QoL) assessment tool needs to be translated and validated in the language of the participants to whom it is administered. Therefore, the oral health impact profile-14 (OHIP-14) scale, developed originally in English, has been translated into different languages like Hindi, Gujrati, etc. The Marathi version of OHIP-14 will be useful to assess in regions where the Marathi language is prominently spoken. Thus, the present study was carried out to translate and validate the Marathi version of the OHIP-14 instrument to measure the oral health-related quality of life. Aims & Objectives: To translate and validate the English Version of the OHIP-14 instrument in the Marathi Language. Materials and Methods: This was a descriptive cross-sectional study in which 128 participants were selected through a convenient sampling method. The English version of the OHIP-14 was translated using the forward-backward translation technique, and participants were given English and the Marathi versions of the OHIP-14 questionnaire. The filled questionnaires were subjected to statistical analysis. Result: The difference in mean scores was not statistically significant(p=0.828). Pearson’s correlation coefficient test was 0.999, suggesting that the translated Marathi version is highly correlated with the original English version. Conclusion: The Marathi version of OHIP-14 is a valid, and reliable instrument for assessing QoL among the population who speak Marathi.
ABSTRACT
Context: Lymphangiogenesis correlates with poor prognosis in Invasive Ductal Carcinoma (IDC) breast. D2-40 antibody, a specific marker for lymphatic endothelium, differentiates lymphatic from vascular endothelium. Therefore, the aims of this study were to estimate lymphangiogenesis using D2-40 antibody and correlate with lymphatic invasion (LI) and axillary lymph node (LN) status and compare lymphatic mean vessel density (LMVD) with Tumor (T) and Node (N) stages and grade of tumor. Methods and Material: The study was conducted on fifty consecutive cases of IDC breast who underwent modified radical mastectomy (MRM) from Jan 2009 to March 2011. Hematoxylin-eosin sections and Immunohistochemistry (IHC) slides were studied along with their LN status. LMVD was counted after D2-40 immunostaining (100x magnification) in three hot spots in peritumoral areas and averaged. LI as opposed to vascular invasion (BVI), and LN status for all cases were assessed. Statistical Analysis: Statistical analysis was done using SPSS software (version 14.0 for Windows). Pearson's correlations, χ2 tests and Mann-Whitney U test were used. Results: Lymphangiogenesis varied from 0 to 58 with mean LMVD of 11. Of 50 cases, five showed no lymphatic vessels in peritumoral areas; of these five, three had positive LNs. 21/50 cases had LI. No statistical significant association was seen between lymphangiogenesis and LI. 34/50 cases had positive LNs. Mean LMVD was higher in patients with N2/N3 stage as compared to N0/N1 stage and was statistically significant (P = 0.013). Conclusions: D2-40 is specific marker for lymphatic endothelium. LI and lymphangiogenesis, as opposed to BVI, are better prognostic indicators in IDC breast.
ABSTRACT
A 24-year-old male presented with features of pneumonia of right lower lobe. Chest radiograph after treatment showed cystic opacities in the right lower zone along with a radio-opaque foreign body at the right cardiophrenic angle. The foreign body was successfully removed via the fibreoptic bronchoscope. It was a very unusual type of foreign body with an equally unusual mode of aspiration.
Subject(s)
Adult , Bronchial Diseases/etiology , Bronchoscopy , Foreign Bodies/diagnostic imaging , Humans , Male , Pneumonia, Aspiration/etiologyABSTRACT
OBJECTIVE: To evaluate the safety and diagnostic value of arthroscopy performed by a rheumatologist. METHODS: Decisions for performing arthroscopy were taken when detailed clinical history-and relevant rheumatological investigations failed to arrive at a definite diagnosis. Arthroscopies were performed under local anesthesia as a daycare procedure. Synovial biopsies taken during procedures were subjected to histopathological examination (HPE). RESULTS: Of the 50 patients enrolled, 39 were males while 11 were females with mean age of 35.5 years. In lower limb oligoarthritis group of patients, three had macroscopic picture of crystal arthropathy, rest of the 29 patients revealed gross picture indicative of non-specific synovitis. While in polyarticular group of eight patients, three had macroscopic picture suggestive of crystal arthropathy (probably polyarticlar gout) while five were indicative of rheumatoid arthritis. In monoarticular disease pattern (n= 10) macroscopic picture findings were as follows- crystal arthropathy-two, tubercular-three, synovial chondromatosis-one and non-specific synovitis-two. HPE of synovium did not correlate in many cases. CONCLUSION: Arthroscopy using a 4 mm scope under local anesthesia in the hands of rheumatologists is a safe daycare procedure. In few cases arthroscopy helped in arriving at a final diagnosis but many patients remained undiagnosed. Both the rheumatologists and the pathologists require further experience in this field.